Molsoft ICM-Pro 3.9

Molsoft ICM-Pro 3.9

Molsoft ICM-Pro is a robust software package for molecular modeling, drug discovery, and bioinformatics. It is a powerful tool for researchers, chemists, and biologists who need to perform complex molecular simulations and analyses. It provides a direct link to the Protein Data Bank (PDB). Once you have downloaded a structure, you can analyze the structure – build Ramachandran plots, superimpose multiple structures, analyze distances and angles, calculate contact and surface areas, display hydrogen bonds, build electrostatic surfaces, and calculate ligand binding pockets.

Features of Molsoft ICM-Pro

• The software allows users to visualize and analyze molecular structures in 3D. This helps in understanding the structure and function of proteins and other biomolecules
• Uses a unique algorithm for protein-ligand docking, which allows users to predict the binding of ligands to proteins accurately
• Provides tools for building homology models of proteins based on their sequences
• Users perform molecular dynamics simulations to study the behavior of molecules over time
• The software provides tools for sequence alignment and analysis, which are essential for bioinformatics research
• Allows users to generate pharmacophore models, which are used in drug discovery to identify potential drug candidates

ICM-Pro Background

ICM-Pro empowers a biologist or chemist with lightning fast access and high quality interactive 3D views to the entire sturctural database. In just a few seconds you can browse hundreds of structures of interest load them, analyze and visualize sequences, structures, alignments, sites, study pockets and bound ligands and drugs, study surfaces, electrostatics, mutations, sequence conservations, perform docking of small molecules as well as protein-protein docking. ICM supports multiple input formats. You can search structural database by field, sequence pattern and get an interactive table for instant viewing. ICM offers a rich graphical environment and powerful views for professional quality of images and molecular animation videos.

ICM: Internal Coordinate Mechanics

ICM-Pro The ICM (‘Internal Coordinate Mechanics’) softwa re project was originally designed around a new molecular mechanics approach and optimization algorithm for peptide prediction, homology modeling, loop simulations, flexible macromolecular dockin g and refinement, and then was extended to graphics, molecular animations, chemistry, sequence analysis, database searches, mathematics, statistics and plotting. ICM-Pro contains an all atom internal coordinate force field and efficient algorithm to perform local and global energy optimization of small or large molecules with respect to an arbitrary sub set of variables. In addition, ICM contains MMFF94 force field for energy optimization in Cartesian space for any organic molecule. ICM-Pro allows users to read, build, convert, refine, analyze a nd superimpose molecules. Includes graphics tools for diverse molecular rendering, perspective viewing, depth cueing, etc. Uses both hardware and side-by-side stereo. Allows saving and printing a screen image as a compact vectorized postscript file in addition to a compressed bitmap.